Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP.

Kousuke TakahashiTaiki NishiyamaNaoki Umezawa Yasumichi Inoue Isamu Akiba Takehisa Dewa Atsushi Ikeda Toshihisa Mizuno

Published in: Chemical communications (Cambridge, England) (2024)

This study explores a new method for delivering therapeutic proteins into specific cells using OLE-ZIP capsules that present IgG. OLE-ZIP capsules is a spherical caspules prepared from amphihilic dimetic coiled-coil peptide, OLE-ZIP. Upon presenting cetuximab, these capsules showed preferential uptake in A431 cells and increased cytotoxicity when loaded with RNase A.

Keyphrases

induced apoptosis
cell cycle arrest
drug delivery
signaling pathway
cell death
radiation therapy
amino acid
protein protein
cancer therapy
wound healing