Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom.

Rafhaella C A CedroDanilo L MenaldoTássia R CostaKarina F ZoccalMarco A SartimNorival A Santos-FilhoLúcia H FaccioliSuely V Sampaio

Published in: The journal of venomous animals and toxins including tropical diseases (2018)

BJ-PLA2-I was characterized as an acidic Asp49 PLA2 that induces acute local inflammation and low cytotoxicity. These results should contribute to elucidate the action mechanisms of snake venom PLA2s.

Keyphrases

oxidative stress
liver failure
respiratory failure
drug induced
ionic liquid
intensive care unit
risk assessment
extracorporeal membrane oxygenation