Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein.
Sophie ClémentCyril SobolewskiDiana GomesAngela RojasNicolas GoossensStéphanie ConzelmannNicolas CaloFrancesco NegroMichelangelo FotiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
MiR-21-5p activation by HCV is a key molecular step, promoting both HCV life cycle and HCV-3a core-induced steatosis and may be among the molecular changes induced by HCV-3a to promote carcinogenesis.