Role of Toll-like receptor 9 signaling on activation of nasal polyp-derived fibroblasts and its association with nasal polypogenesis.
Soo-Kyoung ParkSoung Yong JinSun Hee YeonSung-Bok LeeJun XuYoung Hoon YoonKi Sang RhaYong Min KimPublished in: International forum of allergy & rhinology (2018)
Our data indicates that CpG A-induced fibroblast activation and cytokine production were mediated via TLR9 stimulation in NPDFs. Disrupting this process with an inhibitor targeting TLR9 or its downstream signaling pathways could represent a novel approach to CRS with NP (CRSwNP) therapy.
Keyphrases
- toll like receptor
- inflammatory response
- nuclear factor
- immune response
- signaling pathway
- chronic rhinosinusitis
- dna methylation
- high glucose
- diabetic rats
- electronic health record
- cancer therapy
- big data
- epithelial mesenchymal transition
- bone marrow
- drug induced
- stem cells
- cell proliferation
- cell therapy
- mesenchymal stem cells
- deep learning
- artificial intelligence
- wound healing
- replacement therapy