A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.

Lulu ZhouJinjin ChenYunhao SunKeke ChaiZhounan ZhuChunhui WangMengyao ChenWenmei HanXiaochun HuRuihao LiTianming YaoHui LiChunyan DongShuo Shi

Published in: Journal of nanobiotechnology (2021)

This design of nanocatalytic system offers a new paradigm for combing PARP inhibitor, NQO1-bioactivatable drug and Fenton-reagents to obtain sustained H2O2 generation for tumor-specific self-amplified CDT.

Keyphrases

dna damage
hydrogen peroxide
dna repair
wastewater treatment
emergency department
adverse drug
oxidative stress
electronic health record