Cryptotanshinone Doped Photothermal Synergistic Mxene@PDA Nanosheets with Antibacterial And Anti-Inflammatory Properties for Wound Healing.

Humans are threatened by bacteria and other microorganisms, resulting in countless pathogen-related infections and illnesses each year. Wound infection can delay or even worsen wound healing, endangering patients' lives. Excessive accumulation of reactive oxygen species (ROS) in infected wounds activates strong inflammatory responses. The overuse of antibiotics has led to increasing bacterial resistance, which brings serious threat to human health. Therefore, effective ROS scavenging and bactericidal capacity are essential during wound healing, and the advanced development of collaborative therapeutic techniques to combat bacterial infections is needed. Here, w e have developed a MXene@polydopamine-cryptotanshinone (MXene@PDA-CPT) antibacterial nanosystem with excellent reactive oxygen and nitrogen species scavenging ability, which c ould effectively inactivate drug-resistant bacteria and biofilms, thereby promoting wound healing. In this system, the adhesion of polydopamine nanoparticles to MXene produced a photothermal synergistic effect and free radical scavenging activity, presenting a promising antibacterial and anti-inflammatory therapy strategy. This nanosystem caused fatal damage to bacterial cell membranes, as observed by atomic force microscopy. Moreover, the loading of cryptotanshinone further expanded the advantages of the system, causing a stronger bacterial killing effect and inflammation mitigatory effect with desired biosafety and biocompatibility. In addition, combining nanomaterials and active ingredients of traditional Chinese medicine, this work provided a new rationale for the future development of wound dressings, which contributed to eliminating bacterial resistance, delaying disease deterioration and alleviating the pain of patients. This article is protected by copyright. All rights reserved.