Profiling IOP-responsive genes in anterior and posterior ocular tissues in the rat CEI glaucoma model.
Diana C LozanoYong-Feng YangWilliam O CepurnaBarbara F SmoodyEliesa IngJohn C MorrisonKate E KellerPublished in: bioRxiv : the preprint server for biology (2024)
This study demonstrates the ability to assay IOP-responsive genes in both TM and ONH tissues simultaneously. In the TM, downregulation of TGFβ pathway genes suggest that TM responses may prevent TGFβ-induced extracellular matrix synthesis. For ONH, the initial response to elevated IOP may be protective, with astrocytes playing a key role in these gene responses.
Keyphrases
- genome wide
- extracellular matrix
- genome wide identification
- bioinformatics analysis
- gene expression
- genome wide analysis
- transforming growth factor
- dna methylation
- cancer therapy
- cell proliferation
- oxidative stress
- transcription factor
- copy number
- high throughput
- high glucose
- single cell
- drug delivery
- optical coherence tomography