Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma.

Xiao-Tian ShenSun-Zhe XieXin ZhengTian-Tian ZouBei-Yuan HuJing XuLu LiuYun-Feng XuXu-Feng WangHao WangShun WangLe ZhuKang-Kang YuWen-Wei ZhuLu LuJu-Bo ZhangJin-Hong ChenQiong-Zhu DongLu-Yu YangLun-Xiu Qin

Published in: Experimental hematology & oncology (2024)

Cirrhotic-ECM modulated a NETs enriched TME in HCC, produced an immune suppressive TME and weakened ICI efficiency. Col1 receptor DDR1 could be a potential target synergically used with ICI to overcome ECM mediated ICI resistance. These provide a mechanical insight and novel strategy to overcome the ICI resistance of HCC.

Keyphrases

extracellular matrix
climate change
binding protein