Conventional type 1 dendritic cells protect against gut barrier disruption via maintaining Akkermansia muciniphila in alcoholic steatohepatitis.

Liuyi HaoWei ZhongJongmin WooXiaoyuan WeiHao MaHaibo DongWei GuoXinguo SunRuichao YueJiangchao ZhaoQibin ZhangZhanxiang Zhou

Published in: Hepatology (Baltimore, Md.) (2023)

This study demonstrated that cDC1s protect alcohol-induced liver injury by maintaining A. muciniphila abundance in mice. Targeting cDC1s may serve as a promising therapeutic approach for treating ALD.

Keyphrases

dendritic cells
cell cycle
immune response
drug induced
liver injury
high glucose
diabetic rats
cancer therapy
oxidative stress
antibiotic resistance genes
skeletal muscle
endothelial cells
insulin resistance