Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains.
Oliver WirthsChristina LehnenMerle FrickeIvan TalucciHans-Wolfgang KlafkiBarbara MorgadoSandra LehmannCarolina MünchThomas LiepoldJens WiltfangAgueda RostagnoJorge GhisoHans Michael MaricOlaf JahnSascha WeggenPublished in: Neuropathology and applied neurobiology (2024)
The current findings implicate ADAMTS4 in both the pathological process of Aβ peptide aggregation and in the early detection of amyloid pathology in AD.
Keyphrases