Detection of colonic dysplasia in patients with ulcerative colitis using a targeted fluorescent peptide and confocal laser endomicroscopy: A pilot study.
Giovanni Domenico De PalmaIrene ColavitaGerardo ZambranoMariano Cesare GiglioFrancesco MaioneGaetano LuglioGiovanni SarnelliAntonio RispoPietro SchettinoFrancesco Paolo D'ArmientoFatima Domenica Elisa De PalmaValeria D'ArgenioFrancesco SalvatorePublished in: PloS one (2017)
Ex vivo staining of ulcerative colitis-associated dysplasia using a fluorescent labeled molecular probe and CLE is feasible. In vivo studies on larger populations are required to evaluate the safety and the effective contribution of molecular probes in cancer surveillance of ulcerative colitis.
Keyphrases
- ulcerative colitis
- living cells
- quantum dots
- single molecule
- fluorescent probe
- label free
- papillary thyroid
- public health
- small molecule
- optical coherence tomography
- squamous cell
- computed tomography
- squamous cell carcinoma
- pet imaging
- loop mediated isothermal amplification
- sensitive detection
- photodynamic therapy
- case control