Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes.

Samuel O AntwiMichael HeckmanLaunia WhiteIrene YanVivekananda SarangiKimberly P LauerJoseph ReddyFowsiyo AhmedSwathi VeligintiEllis D Mejías FebresRikita I HatiaPing ChangLaura Izquierdo-SanchezLoreto BoixAngela RojasJesus M BanalesMaria ReigPer StålManuel Romero-GomezAmit G SingalDonghui LiManal M HassanLewis R RobertsTushar Patel

Published in: Human molecular genetics (2023)

Rare functional variants in ABCC2 are associated with susceptibility to metabolic HCC in non-Hispanic whites. PNPLA3-rs738409 is also associated with metabolic HCC risk.

Keyphrases

dna methylation
copy number
genome wide
gene expression
bioinformatics analysis
genome wide identification