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Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.

Satu PallasahoAishwarya GondaneAnni KuivalainenSamuel GirmaySiver MoestueMassimo LodaHarri M Itkonen
Published in: Journal of cancer research and clinical oncology (2022)
We show that CRPC cells, but not normal prostate cells, are addicted on the high activity of the key transcriptional kinases, CDK7 and CDK9.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • prostate cancer
  • cell cycle
  • endoplasmic reticulum stress
  • cell death
  • oxidative stress
  • pi k akt