A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy.
Xuan ZhaoYanjun YangYan YuSiming GuoWenxing WangSumin ZhuPublished in: Chemical communications (Cambridge, England) (2019)
A cyanine-derivative photosensitizer, CYBF2, was synthesized for photodynamic therapy of cancer. The photosensitizer can be activated by red-light with enhanced photostability compared to traditional cyanine photosensitizers. CYBF2 was able to generate singlet oxygen inside the cell mitochondria, which efficiently resulted in apoptosis of cancer cells.
Keyphrases
- photodynamic therapy
- cell death
- fluorescence imaging
- papillary thyroid
- oxidative stress
- reactive oxygen species
- cell cycle arrest
- endoplasmic reticulum
- single cell
- endoplasmic reticulum stress
- cell therapy
- squamous cell
- water soluble
- squamous cell carcinoma
- lymph node metastasis
- drug delivery
- mesenchymal stem cells
- bone marrow
- signaling pathway
- quantum dots