Hemochromatosis alters the sensitivity of red blood cells to mechanical stress.
Kieran J RichardsonAntony P McNameeMichael J SimmondsPublished in: Transfusion (2020)
Given that blood products are commonly exposed to high-shear environments (eg, during high-volume transfusion), venesections from asymptomatic and untreated individuals with HH appear suboptimal for the development of therapeutic RBCs.