Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with COPD.
Nicolas Awad BaddourLaura M PaulinAmanda J GassettHan WooEirc A HoffmanJohn D NewellPrescott G WoodruffCheryl S PirozziIgor BarjaktarevicR Graham BarrWanda O'NealMeiLan K HanFernando J MartinezStephen P PetersAnnette T HastieNadia N HanselVictor E OrtegaJoel Daniel KaufmanCoralynn S SackPublished in: Annals of the American Thoracic Society (2024)
Exposure to ambient air pollution was not associated with interstitial features on CT in this population of heavy smokers with COPD. MUC5B modified the association between pollution and ILA, suggesting that gene-environment interactions may influence prevalence of interstitial lung features in COPD.
Keyphrases
- air pollution
- lung function
- particulate matter
- chronic obstructive pulmonary disease
- heavy metals
- risk assessment
- computed tomography
- cystic fibrosis
- risk factors
- genome wide
- magnetic resonance imaging
- smoking cessation
- image quality
- contrast enhanced
- positron emission tomography
- copy number
- transcription factor
- drinking water
- climate change