The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome.
Mathieu BlotJean-Baptiste BourJean Pierre QuenotAbderrahmane BourredjemMaxime NguyenJulien GuySerge MonierMarjolaine GeorgesAudrey LargeAuguste DargentAlexandre GuilhemSuzanne Mouries-MartinJeremy BarbenBelaid BouhemadPierre-Emmanuel CharlesPascal ChavanetChristine BinquetLionel Pirothnull nullPublished in: Journal of translational medicine (2020)
We identified a unique cytokine response, with higher plasma GM-CSF and CXCL10 in COVID-19 patients that were independently associated with the longer duration of mechanical ventilation. These cytokines could represent the dysregulated immune response in severe COVID-19, as well as promising therapeutic targets. ClinicalTrials.gov: NCT03505281.