African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.

Shaohua FanDerek E KellyMarcia H BeltrameMatthew E B HansenSwapan MallickAlessia RanciaroJibril HirboSimon ThompsonWilliam BeggsThomas NyamboSabah A OmarDawit Wolde MeskelGurja BelayAlain FromentNick PattersonDavid ReichSarah A Tishkoff

Published in: Genome biology (2019)

We observe high levels of genomic variation between ethnically diverse Africans which is largely correlated with geography and language. Our study indicates ancient population substructure and local adaptation of Africans.

Keyphrases

autism spectrum disorder
electronic health record
genome wide
gene expression
machine learning
amino acid
deep learning