SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer.
Shih-Hsuan ChanWen-Hung KuoLu-Hai WangPublished in: Journal of biomedical science (2023)
Our findings indicate that SCEL plays an essential role in the metastatic lung colonization of TNBC by promoting the TNF-α/TNFR1/NF-κB/c-FLIP survival and Akt/Erk1/2 proliferation signaling. Thus, SCEL may serve as a biomarker for adalimumab treatment of TNBC patients.
Keyphrases
- signaling pathway
- rheumatoid arthritis
- pi k akt
- oxidative stress
- end stage renal disease
- cell proliferation
- newly diagnosed
- cell cycle arrest
- chronic kidney disease
- ejection fraction
- lps induced
- small cell lung cancer
- nuclear factor
- prognostic factors
- cell death
- endoplasmic reticulum stress
- patient reported outcomes
- systemic lupus erythematosus
- juvenile idiopathic arthritis
- disease activity