PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination.

Payam GharibaniEfrat AbramsonShruthi ShanmukhaMatthew D SmithWesley H GodfreyJudy J LeeJingwen HuMaryna BaydyukMarie-France DorionXiaojing DengYu GuoSoonmyung HwangJeffrey K HuangPeter A CalabresiMichael D KornbergPaul M Kim

Published in: bioRxiv : the preprint server for biology (2023)

PKC modulation in CNS innate immune cells favors the activation of a beneficial phenotype that promotes myelin regeneration and neuroprotection.

Keyphrases

blood brain barrier
cerebral ischemia
immune response
stem cells
traumatic brain injury
brain injury
lipopolysaccharide induced
protein kinase
lps induced
white matter
subarachnoid hemorrhage
multiple sclerosis
wound healing