IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation.

Hyung-Ju ChoYoun Wook ChungSungmin MoonJu Hee SeoMiran KangJae Sung NamSang Nam LeeChang-Hoon KimAugustine M K ChoiJoo-Heon Yoon

Published in: Allergy (2023)

The effects of IL-4 appear to be mediated through the loss of the deuterosomal population, resulting in the reduction of multiciliated cells. This study also newly suggests cell-specific markers that might be pivotal for investigating respiratory inflammatory diseases.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
stem cells
signaling pathway
cell proliferation
pi k akt