Protein-directed synthesis of ZIF-8 functionalized with a polymer as core-shell drug coatings with antibacterial and anti-inflammatory properties.

We developed a strategy to use lysozyme (Lys) as a template to produce mesoporous zeolitic imidazolate framework (ZIF-8) structures under physiological conditions. Thereafter, an amphiphilic triblock copolymer, PEG-PPG-PEG, was used to form protective core-shell ZIF-8 nanocomposite coatings to protect the encapsulated drug epigallocatechin-3-gallate (EGCG), to achieve notable antibacterial properties against E. coli , S. aureus and MRSA strains. Moreover, nanocomposites exhibited anti-inflammatory activity by counteracting the secretion of cytokines in THP-1 macrophages.