Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes.
Liudmila A StepanovaEugenia S MardanovaMarina A ShuklinaElena A BlokhinaRoman Y KotlyarovMarina V PotapchukAnna A KovalevaInna G VidyaevaAlexandr V KorotkovElizaveta I EletskayaNikolai V RavinLiudmila M TsybalovaPublished in: Journal of biomedical science (2018)
Our results show that highly conserved M2e and HA2-2(76-130) can be used as important targets for the development of universal flu vaccines. The location of the HA2-2(76-130) peptide's insertion into the hypervariable domain of flagellin had a significant effect on the T-cell response to influenza antigens, as seen by forming of multi-cytokine-secreting CD4+ and CD8+ T-cells.