Spreading-dependent or independent Sir2-mediated gene silencing in budding yeast.

Soojin YeomJunsoo OhJung-Shin Lee

Published in: Genes & genomics (2022)

We concluded that S. cerevisiae has two modes of Sir2-mediated gene silencing: one is dependent on chromatin binding and spreading of Sir2, and the other is independent of spreading of Sir2.

Keyphrases

gene expression
dna damage
transcription factor
oxidative stress
binding protein
dna methylation