Presence and predominance of histological grade 3 define cT1HG bladder cancer prognostic groups.
Leonardo Oliveira ReisLuciana S B Dal ColDiego Moreira CapibaribeGustavo B de MendonçaJoão Raphael Fernandes DenardiAthanase BillisPublished in: Investigative and clinical urology (2022)
Grade 3 presence and predominance are independent predictors of progression and disease-specific death and occur in about 40% and 20% of cT1HG, respectively. Describing qualitative and quantitative heterogeneity in urothelial carcinoma grading might improve the stratification of patients. This gives three prognostic high-grade groups based on WHO/ISUP 1973: prognostic grade group I (grade 3 absence), prognostic grade group II (grade 3 presence), and prognostic grade group III (grade 3 predominance).