AMP-activated protein kinase inhibition in fibro-adipogenic progenitors impairs muscle regeneration and increases fibrosis.
Xiangdong LiuLiang ZhaoYao GaoYanting ChenQiyu TianJun Seok SonSong Ah ChaeJeanene Marie de AvilaMei-Jun ZhuMin DuPublished in: Journal of cachexia, sarcopenia and muscle (2022)
These data suggest that AMPK is a key mediator of FAPs apoptosis, and its inhibition due to obesity results in fibrosis of regenerated muscle.
Keyphrases
- protein kinase
- skeletal muscle
- insulin resistance
- stem cells
- metabolic syndrome
- oxidative stress
- weight loss
- type diabetes
- endoplasmic reticulum stress
- cell death
- electronic health record
- high fat diet induced
- liver fibrosis
- big data
- weight gain
- cell cycle arrest
- adipose tissue
- signaling pathway
- body mass index
- data analysis