TAAR1 agonists attenuate extended-access cocaine self-administration and yohimbine-induced reinstatement of cocaine-seeking.
Jianfeng LiuBernard N JohnsonRuyan WuRobert SeamanJimmy VuQing ZhuYanan ZhangJun-Xu LiPublished in: British journal of pharmacology (2020)
Activation of TAAR1 attenuated extended-access cocaine self-administration and stress-induced cocaine reinstatement. These results suggest that TAAR1 agonists are promising pharmacological interventions to treat cocaine use disorder and relapse.