Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways.
Abel TesfaiNiall MacCallumNicholas S KirkbyHime GashawNicola GrayElizabeth WantGregory J QuinlanSharon MumbyJames M LeiperMark Paul-ClarkBlerina Ahmetaj-ShalaJane A MitchellPublished in: PloS one (2017)
In early sepsis profound changes in amine levels were defined by dominant changes in the iNOS canonical pathway resulting in functionally meaningful changes in the ability of plasma to regulate iNOS activity ex vivo.