Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma.

Felix RoyoClara Garcia-VallicrosaMaria Azparren-AnguloGuillermo Bordanaba-Florit Silvia Lopez-Sarrio Juan Manuel Falcon-Perez

Published in: Biomedicines (2024)

Treatment of mixed spheroids with different cytotoxic drugs enables the characterization of drug effects on both hepatocytes and tumoral cells, determining drug specificity effects on these cell types.

Keyphrases

liver injury
drug induced
induced apoptosis
cell cycle arrest
single cell
adverse drug
emergency department
cell death
oxidative stress
signaling pathway