Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.
Emma C JohnsonSandra Sanchez-RoigeLaura AcionMark J AdamsKathleen K BucholzGrace ChanMichael J ChaoDavid B ChorlianDanielle M DickHoward J EdenbergTatiana ForoudCaroline HaywardJon HeronVictor HesselbrockMatthew HickmanKenneth S KendlerSivan KinreichJohn KramerSally I-Chun KuoSamuel KupermanDongbing LaiAndrew M McIntoshJacquelyn L MeyersMartin H PlaweckiBernice PorjeszDavid PorteousMarc A SchuckitJinni SuYong ZangAbraham A PalmerArpana AgrawalToni-Kim ClarkeAlexis C EdwardsPublished in: Psychological medicine (2020)
AUDIT-P PRS was associated with a range of alcohol-related phenotypes across population-based and ascertained cohorts, while AUDIT-C PRS showed less utility in the ascertained cohort. We show that AUDIT-P is genetically correlated with both use and misuse and demonstrate the influence of ascertainment schemes on PRS analyses.
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