Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium.

Liang SongZizhi TangChangsheng PengYueming YangChang GuoDanqing WangLiandi GuoJie ChenCong Liu

Published in: BMC cancer (2020)

Taken together, our study disclose that estrogen-induced genotoxicity and HR deficiency perturb the genome stability of ovarian and fallopian epithelial cells, representing microenvironmental and genetic risk factors, respectively.

Keyphrases

risk factors
estrogen receptor
genome wide
high glucose
diabetic rats
drug induced
endothelial cells
oxidative stress