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Serum metabolomic signatures of gestational diabetes in South Asian and white European women.

Claudia SikorskiSandi AzabRussell J de SouzaMeera ShanmuganathanDipika DesaiKoon TeoStephanie A AtkinsonKatherine Mary MorrisonMilan GuptaPhilip Britz-McKibbinSonia S Anand
Published in: BMJ open diabetes research & care (2022)
We identified a panel of serum metabolites implicated in GDM pathophysiology, consistent in South Asian and white European women. The metabolic alterations leading to larger ratios of glucose to glutamine, glucose to creatinine, arginine to ornithine, and citrulline to ornithine in South Asians likely reflect the greater burden of GDM among South Asians compared with white Europeans.
Keyphrases
  • polycystic ovary syndrome
  • pregnancy outcomes
  • blood glucose
  • ms ms
  • nitric oxide
  • type diabetes
  • metabolic syndrome
  • genome wide
  • adipose tissue
  • uric acid
  • insulin resistance
  • breast cancer risk