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Palatability of pediatric formulations: do rats predict aversiveness?

Sandra SimõesAntónio José AlmeidaJoana Marques Marto
Published in: Drug development and industrial pharmacy (2021)
The results obtained using this simple approach showed that aversiveness is dependent on the assay duration, and that it is possible to predict the aversiveness just by measuring the mass of the tested substance consumption. Moreover, some taste-masking strategies, such as those used in pediatric formulations and corresponding to the addition of sweeteners or flavors, cannot be predicted from rodents BATA model.
Keyphrases
  • high throughput
  • young adults
  • single cell