Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The PREVeNT Trial.
E Martina BebinJurriaan M PetersBrenda E PorterTarrant O McPhersonSarah O'KelleyMustafa SahinKatherine S TaubRajsekar RajaramanStephanie C RandleWilliam M McClintockMary Kay KoenigMike D FrostHope A NorthrupKlaus WernerDanielle A NolanMichael WongJessica L KreftingFred BiasiniKalyani PeriGary CutterDarcy A Kruegernull nullPublished in: Annals of neurology (2023)
Preventative treatment with vigabatrin based on EEG epileptiform activity prior to seizure onset does not improve neurocognitive outcome at 24 months in TSC children; nor delay onset or lower the incidence of focal seizures and drug resistant epilepsy at 24 months. Preventative vigabatrin was associated with later time to onset and lower incidence of infantile spasms. This article is protected by copyright. All rights reserved.