HIV-1 Tat alters neuronal intrinsic excitability.
Walter FrancesconiFulvia BertonMaria Cecilia Garibaldi MarcondesPublished in: BMC research notes (2018)
The exposure of hippocampal pyramidal neurons to Tat for 4 h did not alter intrinsic membrane properties. However, we found a strong increase in intrinsic excitability, characterized by increase of the slope (Gain) of the input-output function, in cells treated with Tat for 24 h. Nevertheless, Tat treatment for 24 h did not alter the resting membrane potential, input resistance, rheobase and action potential threshold. Thus, neuronal adaptability to Tat exposure for 24 h is not applicable to basic neuronal properties. A restricted but significant effect on coupling the inputs to the outputs may have implications to our knowledge of Tat biophysical firing capability, and its involvement in neuronal hyperexcitability in neuroHIV.
Keyphrases
- cerebral ischemia
- healthcare
- induced apoptosis
- hiv infected
- antiretroviral therapy
- hepatitis c virus
- human immunodeficiency virus
- heart rate
- hiv positive
- blood pressure
- cell proliferation
- hiv aids
- heart rate variability
- risk assessment
- blood brain barrier
- subarachnoid hemorrhage
- south africa
- room temperature
- replacement therapy
- endoplasmic reticulum stress
- working memory
- transition metal