Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.

Kirsten BucherFee SchmittBenedikt MothesCarolin BlumendellerDaniel SchällRoland PiekorzEmilio HirschBernd NürnbergSandra Beer-Hammer

Published in: Cell communication and signaling : CCS (2017)

We found that p110γ/δ deficiency in mice induces complex immunological changes, which might in concert contribute to neutrophilia. These findings emphasize a crucial but indirect role of both p110γ and p110δ in the regulation of neutrophil homeostasis.

Keyphrases

high fat diet induced
replacement therapy
wild type
type diabetes
tyrosine kinase
metabolic syndrome
protein kinase
adipose tissue