Role of Microbial Metabolites of Histidine in the Development of Colitis.

Jiaqi WuYuzheng WuWen FengQian ChenDan WangMengyang LiuHaiyang YuYi ZhangTao Wang

Published in: Molecular nutrition & food research (2022)

IMP is able to induce intestinal inflammation, impairs the intestinal barrier, and affects the proliferation of goblet cells. The underlined mechanism may partially contribute to the dysregulation of miR-146b/Notch1 axis.

Keyphrases

induced apoptosis
oxidative stress
signaling pathway
cell cycle arrest
ms ms
microbial community
endoplasmic reticulum stress