Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing.
Li WangJohn P SfakianosKristin G BeaumontGuray AkturkAmir HorowitzRobert P SebraAdam M FarkasSacha GnjaticAustin B HakeSudeh IzadmehrPeter WiklundWilliam K OhPeter M SzaboMegan Wind-RotoloKeziban Unsal-KacmazXin YaoEric SchadtPadmanee SharmaNina BhardwajJun ZhuMatthew D GalskyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The balance of adaptive immunity and protumorigenic inflammation in individual tumor microenvironments is associated with PD-1/PD-L1 resistance in urothelial cancer with the latter linked to a proinflammatory cellular state of myeloid phagocytic cells detectable in tumor and blood.See related commentary by Drake, p. 4139.