Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma.

Xiaoqing ZhangMatias A BustosRebecca GrossRomela Irene RamosTeh-Ling TakeshimaGordon B MillsQiang YuDave S B Hoon

Published in: Clinical and translational medicine (2022)

Our study uncovered that ILF2 amplification of the 1q21.3 chromosome is associated with melanoma progression and triggers a functional downstream pathway in metastatic melanoma promoting drug resistance.

Keyphrases

dna damage response
cell proliferation
binding protein
dna repair
cell cycle
gene expression
nucleic acid
oxidative stress