MiR-146a reduces fibrosis after glaucoma filtration surgery in rats.
Ruiqi HanHuimin ZhongYang ZhangHuan YuYumeng ZhangShouyue HuangZijian YangYisheng ZhongPublished in: Journal of translational medicine (2024)
MiR-146a effectively reduced TGF-β1-induced fibrosis in rat Tenon's capsule fibroblasts in vitro and in vivo, potentially through the NF-KB-SMAD4 signaling pathway. MiR-146a shows promise as a novel therapeutic target for preventing fibrosis and improving the success rate of GFS.
Keyphrases
- cell proliferation
- long non coding rna
- signaling pathway
- long noncoding rna
- pi k akt
- epithelial mesenchymal transition
- transforming growth factor
- oxidative stress
- minimally invasive
- coronary artery bypass
- liver fibrosis
- diabetic rats
- lps induced
- big data
- atrial fibrillation
- immune response
- artificial intelligence
- drug induced
- machine learning
- toll like receptor
- optical coherence tomography
- optic nerve