Effects of 5α-dihydrotestosterone on the modulation of monocyte/macrophage response to Staphylococcus aureus: an in vitro study.

Déborah Cruz Dos SantosRafaela de Souza BittencoutIago Dórea ArêasLarissa Silva C PenaCarolline Florentino AlmeidaBruna Carolina de Brito GuimarãesRafael Santos Dantas Miranda DóreaThiago Macêdo Lopes CorreiaManoel Neres Santos JúniorLorena Lôbo Brito MorbeckTalita Costa Dos SantosClarissa Leal S SouzaSamira Itana de SouzaTelma de Jesus SoaresRegiane YatsudaGuilherme Barreto CamposLucas Miranda Marques

Published in: Biology of sex differences (2023)

We found that DHT acts as an inflammatory modulator in the monocyte/macrophage response induced by S. aureus and females exhibit a better immune defence response against this pathogen.

Keyphrases

methicillin resistant staphylococcus aureus
staphylococcus aureus
dendritic cells
adipose tissue
endothelial cells
oxidative stress
escherichia coli
pseudomonas aeruginosa