Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons.

Daiga KishimotoYohei KirinoMaasa TamuraMitsuhiro TakenoYosuke KunishitaKaoru Takase-MinegishiHiroto NakanoIkuma KatoKiyotaka NagahamaRyusuke YoshimiKazuhiko IgarashiIchiro AokiHideaki Nakajima

Published in: Arthritis research & therapy (2018)

Our data suggest that dysregulated M2-like Mϕ play a proinflammatory role in LN. Bach1 is a potential therapeutic target that could restore the anti-inflammatory property of M2 Mϕ.

Keyphrases

anti inflammatory
electronic health record
human health
machine learning