Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms.

Natalija BogunovicJorn P MeekelJisca MajoléeMarije HekhuisJakob PyszkowskiStefan JockenhövelMagnus KruseElise RiesebosDimitra MichaJan D BlankensteijnPeter L HordijkSamaneh GhazanfariKak K Yeung

Published in: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists (2021)

We present a valuable preclinical model of AAA constructed with patient specific cells with applications in both translational research and therapeutic developments. We observed SMC spatial reorganization in a time course of 5 weeks in our robust, patient-specific model of SMC-EC organization and ECM production.

Keyphrases

extracellular matrix
smooth muscle
induced apoptosis
cell therapy
single cell
heart failure
aortic valve
wastewater treatment
coronary artery
bone marrow
preterm birth