Simvastatin exerts antiproliferative and differentiating effects on MG63 osteoblast-like cells: Morphological and immunocytochemical study.

Antonio Magan-FernándezJ E Fernández-BarberoFrancisco O'ValleR OrtizP Galindo-MorenoFrancisco Mesa

Published in: Journal of periodontal research (2017)

MG63 cells cultured with simvastatin for 72 hours undergo morphological and surface changes. Simvastatin treatment exerts antiproliferative and differentiating effects on these cells as well as promoting recovery of cellular homeostasis.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
signaling pathway
oxidative stress
magnetic resonance
computed tomography
cell proliferation
combination therapy