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Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow.

Florent DuvalMichele De Palma
Published in: Cancer discovery (2019)
Macrophages modulate tumor response to chemotherapy; in this issue, Lossos and colleagues show that high-dose alkylating agents instigate a synthetic lethal program in lymphoma cells that is independent of DNA damage and involves recruitment and priming of macrophages for antibody-mediated tumor phagocytosis. These findings implicate chemotherapy-elicited macrophages as critical effectors of lymphoma clearance during biological therapy.See related article by Lossos et al., p. 944.
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