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Physical models of collective cell motility: from cell to tissue.

Brian A CamleyWouter-Jan Rappel
Published in: Journal of physics D: Applied physics (2017)
In this article, we review physics-based models of collective cell motility. We discuss a range of techniques at different scales, ranging from models that represent cells as simple self-propelled particles to phase field models that can represent a cell's shape and dynamics in great detail. We also extensively review the ways in which cells within a tissue choose their direction, the statistics of cell motion, and some simple examples of how cell-cell signaling can interact with collective cell motility. This review also covers in more detail selected recent works on collective cell motion of small numbers of cells on micropatterns, in wound healing, and the chemotaxis of clusters of cells.
Keyphrases
  • single cell
  • cell therapy
  • induced apoptosis
  • stem cells
  • oxidative stress
  • escherichia coli
  • physical activity
  • mental health
  • mass spectrometry
  • signaling pathway
  • staphylococcus aureus
  • cell death
  • biofilm formation