Effects of polygenic risk for major mental disorders and cross-disorder on cortical complexity.
Simon SchmittTina MellerFrederike SteinKatharina BroschKai RingwaldJulia-Katharina PfarrClemens BordinNina PeuschOlaf SteinsträterDominik GrotegerdKatharina DohmSusanne MeinertKatharina FörsterRonny RedlichNils OpelTim HahnAndreas JansenAndreas J ForstnerFabian StreitStephanie H WittMarcella RietschelBertram Müller-MyhsokMarkus M NöthenUdo DannlowskiAxel KrugTilo KircherIgor NenadićPublished in: Psychological medicine (2021)
Changes in cortical complexity associated with polygenic risk for depression might facilitate well-established volume changes in orbitofrontal cortices in depression. Despite the absence of psychopathology, changed cortical complexity that parallels polygenic risk for depression might also change reward systems, which are also structurally affected in patients with depressive syndrome.