Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance.
Albert E KimKevin W LouAnita Giobbie-HurderKen ChangMishka GidwaniKatharina HoebelJay B PatelMason C ClevelandPraveer SinghChristopher P BridgeSyed Rakin AhmedBenjamin A BearceWilliam LiuElies Fuster-GarciaEudocia Q LeeNancy U LinBeth OvermoyerPatrick Y WenLakshmi NayakJustine V CohenJorg DietrichApril EichlerRebecca HeistIan KropDonald LawrenceJennifer LigibelSara TolaneyErica MayerEric WinerCarmen M PerrinoElizabeth J SummersMaura MaharKevin OhHelen A ShihDaniel P CahillBruce R RosenYi Fen YenJayashree Kalpathy-CramerMaria Martinez-LageRyan J SullivanPriscilla K BrastianosKyrre E EmblemElizabeth R GerstnerPublished in: Neuro-oncology (2023)
This study, one of the largest functional imaging studies for BM, suggests that vascular architecture is linked with ICI efficacy. Studies identifying modulators of vascular architecture, and effects on immune activity, are warranted and may inform future combination treatments.