Rhodium(II)-catalyzed transannulation approach to N -fluoroalkylated indoles.

Olga BakhanovichBlanka KlepetářováPetr Beier

Published in: Organic & biomolecular chemistry (2023)

Copper(I)-catalyzed cycloaddition of substituted cyclohexenyl acetylenes with azido(per)fluoroalkanes afforded 4-cyclohexenyl-substituted N -(per)fluoroalkylated 1,2,3-triazoles. Their rhodium(II)-catalyzed transannulation led to fused N -(per)fluoroalkyl pyrroles and subsequent oxidation provided N -(per)fluoroalkyl indoles.

Keyphrases

room temperature
molecular docking
hydrogen peroxide
ionic liquid