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CDN1163, an Activator of Sarco/Endoplasmic Reticulum Ca 2+ ATPase, Upregulates Mitochondrial Functions and Protects Against β-cell Lipotoxicity.

Ha Thu NguyenCarlos Noriega PoloAndreas WiederkehrClaes B WollheimKyu-Sang Park
Published in: British journal of pharmacology (2023)
Activation of SERCA enhances mitochondrial bioenergetics and antioxidant capability, suppressing cytotoxic insults of palmitate. Our results suggest that targeting SERCA could be a novel therapeutic strategy to protect β-cells from lipotoxicity and the development of type 2 diabetes.
Keyphrases
  • endoplasmic reticulum
  • oxidative stress
  • single cell
  • signaling pathway
  • cancer therapy
  • nuclear factor
  • bone marrow
  • anti inflammatory
  • drug delivery
  • toll like receptor
  • inflammatory response