CDN1163, an Activator of Sarco/Endoplasmic Reticulum Ca 2+ ATPase, Upregulates Mitochondrial Functions and Protects Against β-cell Lipotoxicity.
Ha Thu NguyenCarlos Noriega PoloAndreas WiederkehrClaes B WollheimKyu-Sang ParkPublished in: British journal of pharmacology (2023)
Activation of SERCA enhances mitochondrial bioenergetics and antioxidant capability, suppressing cytotoxic insults of palmitate. Our results suggest that targeting SERCA could be a novel therapeutic strategy to protect β-cells from lipotoxicity and the development of type 2 diabetes.